Clinical Microbiology and Infectious Diseases

Stem Cell Technology

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Stem cell technology is a rapidly evolving field that brings together the efforts of cell biologists, geneticists and clinicians to provide hope for the effective treatment of a wide variety of malignant and non-malignant diseases. Stem cells are defined as totipotent progenitor cells that are capable of self-renewal and differentiation according to multiple lineages. 1 Stem cell survive well, show stable division in culture, and are ideal targets for in vitro manipulation. Early studies focused on hematopoietic stem cells, but stem cells are also recognized elsewhere. Research on solid tissue stem cells is not as advanced as research on hematopoietic stem cells. This is because it is difficult to reproduce the necessary and accurate 3D alignment and the close interactions between cells and extracellular matrix present in solid organs. However, the ability of tissue stem cells to integrate into cytoarchitecture under the control of the host's microenvironment and developmental cues makes them ideal for cytoarchitecture. This overview briefly describes the current state of research and the clinical status of treatment based on hematopoietic stem cells and tissue stem cells.

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