Clinical Microbiology and Infectious Diseases

Nutrition and Bipartite Metabolism of Intracellular Pathogens

Pathogens or infectious agents develop gradually by using this bipartite mechanism. In this metabolism host supplies their nutrients to pathogens there by the acidity of pathogens is increased gradually. The host acts as a nutrient medium or slot for pathogens, because of this nature of host lifespan of the host cell will be reduced. Many intracellular pathogens like Legionella pneumophila, Coxiella burnetii and Listeria monocytogenes have developed bipartite metabolism in their hosts. This metabolism enables catabolism and anabolism of nutrient agents which has the capability of infective agent recognition. Strategies of pathogen manipulation of host nutrients could serve as therapeutic targets.