Medical and Clinical Microbiology

Biography

Biography: Mohd Hasmizam Razali

Abstract

Statement of the Problem: Currently, there are approximately 165 million cases worldwide across different types of wounds either close or open wounds which is requiring the wound treatments. Thus, the demands in wound treatments are extremely huge and predicted to grow annually over 6% (Franco, 2010). The application of biological materials in form of solutions and creams for drug delivery to the wounds are not very effective as they rapidly absorb fluid during the process and lose their physical, mechanical properties and become unstable (Boateng et al., 2008). For this reasons, the use of wound dressing is preferred as they provide better exudate management and prolonged residence at the wound site. Methodology & Theoretical Orientation: There are more than 3000 types of wound dressing products available in market (Nelson & Dilloway, 2002). However, wound dressing based on gellan gum has received great attention due to their biocompatibility and biodegradability properties. Although gellan gum has been reported to biocompatible on a few live cells, but researchers keep working to improve the proliferation rate on gellan gum thin film. Sankar et al. (2014) was reported titanium dioxide nanoparticles loaded with Origanum vulgare plant have delivered a novel therapeutic route for wound treatment in clinical practice and their study shows significant wound healing activity in Albino. Moreover, the inclusion of nanosized materials into biopolymers also improved cell biocompatibility, antibacterial and antiviral properties (Mathew & Kuriakose, 2013; Nitta & Numata, 2013). Thus, in this study TiO₂ nanotubes was incorporated into gellam gun (GG) biopolynmer thin film in order to enhance the antibacterial properties and cell proliferation for wound healing. Findings: Antibacterial studies proved the GG incorporated TiO₂ nanotubes has high antibacterial activities against Escherichia coli and Staphylococcus aureus. In vivo evaluation on rat confirms that the GG incorporated TiO₂ nanotubes showed faster wound healing, more complete re-epithelialization and denser collagen deposition properties. Conclusion & Significance: The findings demonstrate that the prepared GG incorporated TiO₂ nanotubes thin films has a big potential as wound dressing for faster healing process.