8^th Clinical Microbiology Conference

Clostridium difficile infection (CDI) is one of the most common gastrointestinal complications after an antimicrobial treatment. It is estimated that CDI after the pneumonia treatment is connected with a higher mortality than other causes of hospitalization. The aim of the study was to assess the relationship between individual antibiotic intake and mortality of Clostridium difficile infection after pneumonia treatment. A retrospective analysis of 217 patients with CDI in the Internal Medicine Ward, Medical University of Warsaw was conducted. In 94 pa-tients who were treated for pneumonia CDI was diagnosed. To emphasize a correlation be-tween mortality of CDI and the antibiotic therapy the fraction test was performed. 94 patients 52% went through a severe and complicated infection. Among severe cases 62.5% (n=30) of records were provided respectively with ceftriaxone, 45.8% (n=22) ciprofloxacin, 41.6% (n=20) amoxicillin with clavulanic acid, 29.2% (n=14) clarithromycin, 22.9% (n=11) cefuroxime, 20.8% (n=10) imipenem. The fraction test revealed statistically significant mortality rate in a group of patients who were provided with ceftriaxone. The study shows there is a correlation between the antibiotic treatment of pneumonia and mortality rate in pa-tients who developed CDI due to the chosen therapy. There was a significant mortality rate according

to ceftriaxone intake; therefore, it should be avoided in patients with the higher risk of CDI.