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Giulio Tarro

Giulio Tarro

President Foundation T. & L. de Beaumont Bonelli for cancer research, Italy

Title: Human vaccines for infectious and non infectious diseases

Biography

Biography: Giulio Tarro

Abstract

The Variola major, the virus thatcauses the smallpox, lethal virus in the 30% of the cases, waseraticated in 1979 in the human species, thanks to a capillaryvaccination on global scale.rnRecently the Word Health Organization (WHO) declaredthat India and Southeast Asia are polio-free, really a greatachivementsince the vaccine for polio, an infectiousdeseasethat can cause paralisis, wascertificatedsafe and usefulonly 60 years ago.rnLast year over 800 milliondoses of combinationvaccines are going to be used to vaccinate Chinesechildrenwhereas more than 20 millionchildrenworldwide do notreceiveone or more importantvaccinationsthatwouldprotectthem from atleastonepreventabledisease.rnHBV virus, responsible for epatitis B infection, isable to prevent 50% of alllivercancers. Human Papilloma Viruses (HPV) havebeencorrelated with the cervicalcancer (genotypes 16 and 18 particularlyoncogenic in humans): the USA Food and Drug Administration (FDA) in 2006 released the first vaccine against HPV.rnLong years of researchwhererequired for busting the new system to fightcancer. Researchisgoing to obtain the complete sequence by proteomicsapproaches, in order to achieveadequateantigenpreparationsthatmight be used to generate assays for a specificanticancer vaccine.rnFinally, the ability of the immune system to recognize a tumor-associatedantigen, thusenablingdevelopment of a vaccine approach for therapeuticapplication, represents a main target of thisfield of researchrn