4th Clinical Microbiology and Microbial Genomics Conference

Biography

Biography: John G Thomas

Abstract

National and International studies in 2007/8 unmasked the hidden microbial world of Homo sapiens and the partnering of pro-caryotes and eucaryotes, coining the new Term “Super Organism” . Additional studies highlighted the importance of this balance (“Dual Citizenship”) in disease and health. Recognizing the occurance of human disease over time , we constructed a “Microbial Clock”, keyed to age and diseases , focusing on organisms associated with these selected diseases highlighting an ageing population , often tumor associated . 10 targeted Chronic Disease were selected by economic impact, potential management, infectious disease partnering , and age of occurance . The “Microbial Clock” was arbitrarily divided into 4 quadrants associated with 4 age groups( 0- 12 yr with a subset of new born; 12- 18 yr ,Adolescent ; 19 -55yr , Adult ; 56 yr and older , Aged, recognized by color and potential consequences Targeted Diseases could be grouped by age , studying population dynamics, emphasizing the percentage of population at -risk ; diseases highlighted Autism and Asthma, Diabetes and Obesity selected tumors /cancers and Dementia . Shifts in microbial populations could be correspondingly over-layed to these age groups, creating a 4 quad “Microbial Clock “, emphasizing a potential partnering of 26 microbes representing all phyla 6 , age and disease in 4 distinct color zones . An example was F. nucleatum, which over the 4 time zones changed from normal flora (Green) to distinct dental pathogen (Orange) to tumor stimulator in colo-rectal-cancer (Red), high lighting it possible role in tumorgenisis in the Aged. Selected microbial populations were unbalanced in selected diseases and could pose a unique target and marker in disease progression ( Bio-Marker ), highlighting a microbialpathogenicity/trigger and use of eco-friendly “restorative microbiology”(Probiotics) in management, matched to age. The Orange and Red zone unmasked the potential mutagenisis and tumor marker for selected microbes and the migratory nature of oral microbiota .