Joanna S Brooke
DePaul University, USA
Title: Effects of select chemicals on the opportunistic multidrug-resistant bacterial pathogen, Stenotrophomonas maltophilia and its bio-film
Biography
Biography: Joanna S Brooke
Abstract
Stenotrophomonas maltophilia is a global human opportunist which is associated with infections that include those of the respiratory tract, bloodstream, soft tissue and bone, eye, heart and brain. S. maltophilia infection is of significant concern in immunocompromised patients and a high mortality rate has been reported. This bacterium is found in water, washed foods, plant roots and soils and animals. Hospital-acquired and community-acquired infections of S. maltophilia have been reported. Antimicrobial resistance surveillance monitoring networks worldwide report a steady rise in the number of drug-resistant strains of S. maltophilia recovered from patients. S. maltophilia is resistant to a wide range of antimicrobials, including beta-lactams, fluoroquinolones, aminoglycosides, polymyxins, macrolides, carbapenems, tetracylines, chloramphenicol and trimethoprim-sulfamethoxazole. Intrinsically drug-resistant strains of S. maltophilia have been recovered from environments outside of the clinical setting. New strategies are needed to prevent/challenge S. maltophilia infections. S. maltophilia forms biofilms on medical devices and on living tissues. One of the goals of our laboratory is to study the molecular mechanisms used by this pathogen to form biofilms and subsequently identify suitable targets for treatment strategies to prevent/inhibit S. maltophilia growth, biofilms, and cell survival. We have observed that S. maltophilia is able to form biofilms on polyvinyl chloride, polystyrene and glass. We have screened various chemicals and observed that the growth and biofilm formation of S. maltophilia can be hindered. We will report on recent studies that examine the effects of select chemicals on the growth, biofilm development and survival of S. maltophilia