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Ratana Lawung

Ratana Lawung

Mahidol University, Thailand

Title: Prevalence and distribution of beta-lactamase coding genes in third-generation cephalosporin-resistant Enterobacteriaceae isolates in Thailand and Vietnam


Biography: Ratana Lawung


Antimicrobial resistance is one serious global health problems especially in Asia. Dissemination of third-generation cephalosporin-resistant (ESC-R) bacteria, carbapenem resistance bacteria, and emergence of plasmid mediated colistin resistance (mcr-1) bacteria play important concerns. Also presence of integron class 1 (IL-1) highlights the risk of rapid spread of resistance genes especially in clinical settings. Molecular methods for identification of broad spectrum antimicrobial resistance are high benefit. Detection methods were developed for the CTX-M extended-spectrum-β-lactamase (CTX-M-ESBL), plasmid-mediated AmpC cephalosporinase (pAmpC), carbapenemase, mcr-1, and integron class 1 (IL-1) genes in Enterobacteriaceae and identification of carbapenemase and mcr-1 genes in Acinetobacter and Pseudomonas aeruginosa. Difference in geological regions and treatment prescription may cause diversified resistance patterns. Our methods were successfully applied to study the dissemination of resistance genes at various regions. This study indicated that ESC-R bacteria harboring with one and multiple β-lactamase genes were disseminated in Thailand and Vietnam. In conclusion, epidemiological study of drug resistance pathogen should be strengthened, to provide strong guidance for clinical management, promote effective treatment of patients and use for prevention and control the spread of this antimicrobial-resistant organism.